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Specificity of association, this is taken by the degree of exposure to the suspected agent to predict the outcome. Temporal Relation of association, exposure to the causing factor of disease must proceed to the onset of disease. Coherence of association, Disease progression and effects on the settings must be explained clearly reflect the results.
Smoking has now been identified as the major cause of heart disease, stroke, and several different forms of cancer in organs other than the lungs, without including the large variety of other health problems. The majority of deaths caused by cigarette smoking are mainly caused by heart disease or lung cancer...
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