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The role of the UV light in the p53 mutations is shown by the double base change in three of the tumors which is known to be induced by UV. These mutations caused by the UV light are substitution mutations which can cause great harm because once it has mutated it replicates as the mutated gene. The squamous cell carcinoma of the skin is an ideal cancer for determining which of the many steps in tumorgenesis is carcinogen related.
The materials and methods used to research this were as such. Patients used for the tests were from the greater New York City or Uppsala, Sweden, areas. The tissue that was gathered for this testing were blocks of neutral-formalin-fixed squamous cell carcinogens for which the tumor originated in sun-exposed skin and as well the epidermis contained at the least 50% bordering invasive carcinoma...
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