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There are approximately 80,000 individuals in the United States with sickle cell disease. The red blood cells of people with sickle cell disease contain an abnormal type of hemoglobin, the oxygen-carrying pigment, called hemoglobin S. The deficiency of oxygen in the blood causes hemoglobin S to crystallize, distorting the red blood cells into a sickle shape, making them fragile and easily destroyed, leading to anemia. The "sickled" blood cells then are unable to squeeze through the smaller blood vessels (arterioles and capillaries). Because people with sickle cell anemia don't have enough normal red blood cells, they get tired more easily...
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