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These factors include:
Lowered immunity: When one's immune system is healthy, macrophages can often successfully wall off TB bacteria, but one's body can't mount an effective defense if the resistance is low. A number of factors can weaken one's immune system. Having a disease that suppresses immunity, such as HIV/AIDS, diabetes and receiving treatment with corticosteroids, arthritis medications or chemotherapy drugs. Other factors include age, history of substance abuse (alcohol or drug) and malnutrition.
Close contact with someone with infectious TB: In general, one needs to spend an extended period of time with someone with untreated, active TB to become infected...
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