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It is multifaceted and hierarchical in its expression with subtle changes occurring simultaneously at the molecular, cellular, tissue and organ levels. The considerable heterogeneity that characterises many species, particularly humans, and the complexity of environmental interactions and polygenic controls, results in an enormous phenotypic variability being associated with ageing. This variability is frequently confounded by the symptoms of underlying pathology and invariably increases between individuals with ageing.
It is therefore necessary to extract the essential attributes of the ageing process from this phenotypic complexity as a foundation on which to base an understanding of the biochemical processes involved...
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