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The presynaptic neuron contains the neurotransmitters, mitochondria, endoplasmic reticulum, and other cell organelles. The postsynaptic neuron contains receptor sites for the neurotransmitters in the presynaptic neuron. The synaptic cleft is the space between the presynaptic and postsynaptic neuron.
The arrival of an action potential normally causes the release of neurotransmitters from the presynaptic neuron. The action potential travels down to the axon terminal of the presynaptic neuron. Each axon terminal becomes swollen forming a presynaptic knob. There is a depolarisation of the presynaptic membrane resulting from the action potential...
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