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AD is caused by the formation of plaque and neurofibrillary tangles (NFTs) leading to extensive neuron death in the brain and results in a destructive pathway. Some other factor causing AD are over expression of amyloid precursor protein (APP), presenilins, or tau protein genes to cause the over-production and build up of the plague. This paper explores these neuro-pathological problems that leads to the developing of AD in rodent transgenic animal and non-rodent transgenic animal such as the fruit fly Drosophila melanogaster and the nematode Ceanorhabditis elegant to learn from and develop treatment and therapy for the human condition (Spires and Hyman, 2005)...
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Common topics in this essay:
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