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Essay text:
None of the
conventional anti-tuberculosis drugs are able to target these persisting
bacilli. Development of drugs against such persisting bacilli is a
constant challenge since the physiology of these dormant bacteria is
still not understood at the molecular level. Some evidence suggests
that the in vivo environment encountered by the persisting bacteria is
anoxic and nutritionally starved. Based on these assumptions,
anaerobic and starved cultures are used as models to study the
molecular basis of dormancy. This review outlines the problem of
persistence of M. tuberculosis and the various in vitro models used to
study mycobacterial latency...
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