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This embryo is just barely twice the diameter of a human hair. Using a thin glass needle, he was able to extract the blastocyst's inner cell mass (Stem Cell Now pg 2). Our understandings of stem cells have come a long way since this original discovery.
For a time, contemporary science believed that stem cells had a few main qualities including: irreversible differentiation, self-renewal, and hierarchical development (3). It was believed that starting with a totipotent zygote, cell types would become more and more differentiated until they reached a very specific tissue (3). On their path, they would become pluripotential (can become any cell type), multipotent (more specific, but can only become a small range of similar tissue), and then finally a fully differentiated cell (3)...
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