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This chemical change occurs in healthy brain's, which experience sadness, but ends after the unpleasant stimulus is removed. In people suffering from depression this chemical change does not correspond to any particular stimulus. Symptoms of depression are often incapacitating and include severe and extended sadness, feelings of worthlessness, feelings of emptiness, irritability and anxiety (Reichert, Spake).
The first major study conducted on the matter in the United states found that St John's wort had negligible benefits on patients with major depression with no statistically significant benefits more then those produced by a placebo (Shelton)...
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