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When sickle hemoglobin releases oxygen molecules tend to join together this causes the hemoglobin to form rods in turn alters the shape of the red blood cell itself. These red blood cells have two characteristics that are not helpful, cells are rigid and fragile. Normally, red blood cells are round, soft and pliable. This is so they may move through small blood vessels. However, the red blood cells of someone with Sickle Cell Anemia will not move through these vessels, this is due to their rigidity, plug the blood vessels and occasionally obstructing the flow of blood. This usually causes tissue and/or organ damage...
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