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Sickle cell anemia occurs when an abnormal form of hemoglobin is produced. HbS molecules tend to clump together, making red blood cells sticky, stiff, and more fragile, and causing them to form into odd curved, sickle shape, red blood cells containing HbS can go back and forth between being shaped normally and being sickle shaped until they eventually become sickle shaped permanently. Instead of passing through the bloodstream easily, these sickle cells can cause clogging of the blood vessels and deprive the body's tissues and organs of precious oxygen they need to stay healthy.
Usually red blood cells last about 4 months in the bloodstream; fragile sickle cells break down after only about 10 to 20 days, which usually causes anemia...
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