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About one of every 500 males born has Klinefelter's syndrome.
If a male gamete containing the Y chromosome fertilizes an egg containing no X chromosome, then that embryo will fail to develop because it is essential that every human must have at least one X chromosome. There appears to be just too much important genetic information on the X chromosome not to have one.
There are also special cases where, because of non-disjunction again, a woman can have 3 X chromosomes. These women are called triplo-X and can show tallness and have menstrual irregularities. Men who receive an X from their mother and a double Y from their fathers have an XYY combination and have a condition called Jacob's syndrome...
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