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This 'information' is coded as targeting signals which enable the cellular transport machinery to correctly position a protein inside or outside the cell. The information is contained in the polypeptide chain or in the folded protein. The continuous stretch of amino acid residues in the chain that enables targeting are called signal peptides. This short amino acid sequence functions as a postal code for the target organelle or location, and the synthesized protein can be transported either co-translationally or post-translationally, depending on the protein.
Proteins that are part of the secretory pathway are transported co-translationally which means that the proteins are translocated to the ER lumen as they are being synthesized, where they are glycosylated and where molecular chaperones aid proper folding...
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