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Essay text:
This justifies the withdrawal of rofecoxib from the market.
Introduction
Rofecoxib is a non-steroidal anti-inflammatory drug (NSAID) which selectively inhibits the cyclooxygenase-2 (COX-2) enzyme.1 It was developed by Merck & Co. for the treatment of acute inflammation in joints, without causing the gastrointestinal side effects associated with traditional NSAIDs.1,2,3 Although evidence indicates that rofecoxib is as effective as traditional NSAIDs in relieving pain, serious concerns about its cardiovascular safety have arisen.1 In the Vioxx Gastrointestinal Outcomes Research (VIGOR) study, patients taking rofecoxib had a much higher risk of myocardial infarction (MI) than patients taking the comparator drug naproxen (See Fig...
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