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Rheumatoid Arthritis

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Title: Rheumatoid Arthritis

Essay Details:

Subject: Science

Author: Stephanie S

Date: August 17, 2015

Level: University

Grade: A

Length: 15 / 4202

Essay text:

Elevated expression of MIF in the circulation and in the synovial joint has been documented in rheumatoid arthritis. MIF also has been linked to the development of joint damage and disease pathology in experimental animal models. We describe herein a novel CATT-tetranucleotide repeat polymorphism at position -794 of the human Mif gene and show that it functionally affects the activity of the MIF promoter in gene reporter assays. We describe four genotypes which comprise 5, 6, 7, or 8-CATT repeat units and show that the 5-CATT allele has the lowest level of basal and stimulated MIF promoter activity in vitro...

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