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Tumor regression or cellular arrest due to the reactivation of p53 in mice with autochthonous tumors can also be foreseen. The importance of autochthonous tumors is that they originate in the organism and mimic real life events.
3. Collected data from this experiment support the conclusion that sustained inactivation of p53 is required for the maintenance of primary, autochthonous lymphomas and sarcomas. If p53 is reactivated in a tumor, then tumor regression may occur.
4. Data did support the conclusions and the hypothesis in this paper.
• MRI images (Figure 2 d,e) show tumor growth in vivo where p53 was not reactivated...
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