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The three-carbon pyruvate loses two of its hydrogen atoms and also a carboxyl grouping. A two-carbon acetyl group, free energy, and carbon dioxide are made. Coenzyme A links to the acetyl group, and captures the free energy that is there. A little of the energy that was made gets saved when NAD+ is reduced to NADH+H+. Some of the rest of the remaining energy is stored temporarily when the acetyl group combines with CoA. Pyruvate dehydrogenase complex catalyzes the reaction. This catalyzing agent alone contains 72 polypeptide chains. Acetyl coenzyme A is the product of this cycle, and moves into the citric acid cycle to continue the process...
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