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A world-famous example is Fleming’s discovery of penicillin as a treatment for infectious diseases. Upon returning from a holiday, he realised he had not cleaned up his bacterial plates before leaving. When he took them out, he noticed a strange thing: fungus had grown on the plates and killed all the bacteria in its vicinity. Fleming deduced that the fungus produced an ‘antibiotic’ substance and went on to isolate it.
Modern biotechnology asks for a more rationalistic approach: the development of a drug should be explicitly based on a thorough understanding of the molecular mechanisms that cause a specific disease...
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