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Outbreaks can be triggered by infection, such as strep throat, drug-use, psychological stress, hormonal changes and skin injury. The exact cause is still unknown; however, research has provided some interesting insights into the pathophysiology of psoriasis.
The most evident pathophysiological change leading to psoriasis is hyperproliferation and abnormal differentiation of keratinocytes. Keratinocytes are cells in the epidermis that produce keratin, a “protein that helps protect the skin and underlying tissues from heat, microbes, and chemicals.” (Tortora & Derrickson, 2006). Patients with psoriasis shed and replace these cells every two to six days...
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