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Since the term was first used by Wetlaufer (1973) a number of definitions exist reflecting author bias, however all of the definitions agree that domains are independently folding compact units. Domains are frequently coded by exons and therefore have specific functionality. Among the many descriptions of protein domains the two most striking and simple are " Protein evolutionary units" and "Basic currency of Proteins".
Domains may be considered to be connected units, which are to varying extents independent in terms of their structure, function and folding behaviour. Each domain can be described by its fold...
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