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Consequently, derangements in insulin signalling have widespread and
devastating effects on many organs and tissues.
The Insulin Receptor and Mechanism of Action
Like the receptors for other protein hormones, the receptor for insulin is embedded in the plasma
membrane. The insulin receptor is composed of two alpha subunits and two beta
subunits linked by disulfide bonds. The alpha chains are entirely extracellular and house
insulin binding domains, while the linked beta chains penetrate through the plasma membrane.
The insulin receptor is a tyrosine kinase. In other
words, it functions as an enzyme that transfers
phosphate groups from ATP to tyrosine residues on
intracellular target proteins...
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