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When the repressor is bound to the operator, it blocks the promoter. Therefore the RNA polymerase either can't bind to the DNA molecule or it can't begin its movement along the molecule. No transcription can occur. The repressor depends on the effector, which allows it to bind to the molecule. It can either activate or inactivate the repressor.
The lac operon in bacterial cells gave the first clue that such a gene occurred in cells. When lactose is present, the first step in its metabolism is to produce a closely related sugar which binds to and inactivates the repressor, removing it from the operator...
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