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Neuropeptide Y was first reported as a peptide abundant in brain tissue in 1982 [4], and has since been extensively implicated as a pivotal component of neurocircuitry subserving energy balance. During the period since its isolation, emphasis has moved away from clear cut and perhaps oversimplified anatomical divisions of feeding and satiety centres toward a description of the specific neurotransmitters that modulate feeding behaviour and energy expenditure.
1.1 NPY and its receptors
NPY exerts most of its biological effects through five G-protein coupled receptors termed Y1, Y2, Y4, Y5 and y6 that mediate either inhibition of adenylate cyclase or increases in intracellular calcium...
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