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Researchers injected the interleukin-1 receptor antagonist (IL-1Ra) gene into the women's affected joints. IL-1Ra protein blocks the actions of interleukin-1 protein, which plays a role in the breakdown of cartilage that occurs in arthritis patients.
"The idea is that by remaining in place, the new gene can continuously block the action of the interleukin-1 within the joints. In essence, the gene becomes its own little factory, continuously working to alleviate pain and swelling," principal investigator Christopher Evans, director of the Center for Advanced Orthopaedic Studies at Beth Israel Deaconess Medical Center in Boston, said in a Harvard Medical School news release...
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