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The genetically engineered mice were tripped up by the tiniest exposure to nicotine ? a concentration 1/50th of the strength of nicotine coursing through a typical smoker's blood. Once hooked, the mice experienced classic signs of nicotine dependence that keep smokers puffing, the research team reports Friday in the journal Science.
"Dependence-related behaviors, including reward, tolerance, and sensitization, occur strongly and at remarkably low nicotine doses" in the mice, the research team wrote.
In humans, reward arrives as a pleasant little jolt of dopamine, a calming brain chemical unleashed by nicotine...
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Common topics in this essay:
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