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The effectiveness of synapses can be changed with the presence of a psychoactive drug. These drugs work by affecting the neurons either pre-synaptically or post-synaptically. For example, Prozac is a reuptake inhibitor for serotonin that causes it to enhance its effect along with cocaine, where it blocks the reuptake of dopamine, leaving the neurotransmitters in the synaptic gap for a longer amount of time. Psychoactive drugs like these causes an imbalance of neurotransmitters in the brain. Other ways that psychoactive drugs can work is to produce more neurotransmitters, imitate the actions of an original neurotransmitter and bind to the receptors, or bind to the receptor site and block activation...
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