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The microfluidic channels, fabricated by soft lithography, have been used for a decade. Dr. Paul W. Bohn, Centennial Professor of Chemical Sciences at the University of Illinois at Urbana-Champaign, sees the advance to multilayered liquid chromatography as a key step in the development of micro total analysis systems (iTAS), which would involve such new applications as injection, collection, mixing, switching and detection. Recently he has been studying the analyte responses to various constraints applied to the system and its deviations in behavior from that of a similar system on the macro scale...
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