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INTRODUCTION
The developments in the use of microbubbles have shown the shift from using microbubbles as contrast agents to drug delivery of fibrinolytic agents and now to manipulation of microbubbles in enhancing cavitations by lowering the threshold energy of cavitation[1-4]. With this new finding,
Ischemic stroke patients could have a glimpse of hope for a cure without going through surgeries or drug consumption.
With ultrasound, it has been found that cavitation which occurs at megahertz frequencies produce sufficient magnitude to lyse blood cells[5]. As microbubbles tend to lower the threshold of cavitations and it is shown in [6, 7] that frequency range of 25-37 kHz ultrasound and microbubbles alone can enhance thrombolysis, the study of manipulation of ultrasound with microbubbles is crucial in order to get the maximum results out of this finding [8-13]...
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