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These beta cells are located in the pancreas in clusters known as the islets of Langerhans. Insulin is a small protein produced as part of a larger protein to ensure it folds properly. In the protein assembly of insulin, the messenger RNA transcript is translated into an inactive protein called preproinsulin. Preproinsulin contains an amino-terminal signal sequence that is required in order for the precursor hormone to pass through the membrane of the endoplasmic reticulum (ER) for post-translational processing. The post-translational processing clips away those portions not needed for the bioactive hormone...
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