Insulin

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Title: Insulin

Essay Details:

Subject: Science

Author: Robin M

Date: November 10, 2014

Level: University

Grade: C

Length: 36 / 10715

Essay text:

Direct evidence for this function came in 1889, when Minkowski and von Mering showed that pancreatectomized dogs exhibit a syndrome similar to diabetes mellitus in humans. Chemistry.Insulin was purified and crystallized by Abel within a few years of its discovery. Sanger established the amino acid sequence of insulin in 1960, the protein was synthesized in 1963, and Hodgkin and coworkers elucidated insulin's three-dimensional structure in 1972. Insulin was the hormone for which Yalow and Berson first developed the radioimmunoassay The ? (or B) cells of pancreatic islets synthesize insulin from a single-chain precursor of 110 amino acids termed preproinsulin...

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