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In vivo neocortical neurons receive continuous excitatory and inhibitory postsynaptic potentials (EPSPs/IPSPs). Such an intense background activity arises from the cortical presynaptic neurons, spontaneously spiking at low rates, and it induces the postsynaptic membrane voltage to fluctuate, resulting in an irregular spike emission. Under such conditions, the biophysical awake cortical properties of the neurons are substantially altered compared to those of a neuron at rest. So observations in vitro may not directly transfer to the in vivo situations.
In this essay I'm going to argue that the research of Wolfart et al (2005) is compatible with the findings of Destexhe, Rudolph & Pare (2003)...
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