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Hereditary (approximately 80% of patients)
a. Sex-linked, recessive trait--- caused by a gene carried on the X chromosome.
b. Transmitted by asymptomatic females.
c. Appears in males who have the hemophilic gene on their X chromosome.
d. Affected males may pass the gene to female offspring, making them carriers.
e. May appear in females if a female carrier bears offspring w/ a hemophiliac male (rare).
2. Spontaneous mutations may cause the condition when the family history is negative for the disease (about 30% of patients).
3. The basic defect is in the intrinsic phase of the coagulation cascade...
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