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Females have two X chromosomes for their sex chromosomes. They must carry the defective gene on both to have hemophilia. They must have it on one to carry it, and are then able to pass it on to their offspring. Males have X and Y chromosomes for their sex chromosomes. They only have one X chromosome, therefore only require a single dose of the defective gene to express the deficiency. Fifty percent of the male offspring of female carriers have the disease, and fifty percent of their female offspring are carriers. This is why this disease mostly affects men.
Severity of symptoms can vary with the disease, but bleeding is the central symptom...
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