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From this information it was discovered that there is also a lower ratio of weaker adrenal androgens (delta 4-androstenedione and dehydroepiandrosterone) found in youths with this disease. It was once believed that there was an imbalance in the ratios of testosterone to estrogen or estradiol, but this is now known to be untrue.
There are three areas the can be attributed to the cause of gynaecomastia: physiologic, pathologic and pharmacologic. "Enlargement of the male breast can be a normal physiologic phenomenon at certain stages of life or the result of several pathologic states."(Isselbacher, 2037) In the case of physiologic gynaecomastia the disease can occur in a newborn baby, at puberty or at any time in a man's life...
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