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Hence, insulin has long been a target for the treatment of DM. In DM Type I, intravenous or subcutaneous insulin injection has often been the norm. Iatrogenic insulin administration, insulino-mimetics, or insulin-secretagogues have been the major modalities of treatment for DM type II; however, these treatments do not address the resistance in peripheral tissues to insulin. Essentially, these methods offer a "brute-force" method of treating hyperglycemia, by increasing levels of a decreasingly effective hormone (Champ).
Under normal physiological conditions, insulin binds to the insulin receptor and becomes phosphorylated as a result...
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