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So for an inverse agonist this would mean a decreasing the activity of the receptor.
The structure of carazolol is shown below:
Questions:
? Diagram of GPCR from the view of looking across the membrane with helix 1 on your right:
? Diagram of GPCR from the view of looking down on top (from outside the cell uppermost):
? Q. What interactions (i.e. within 5A) does this cholesterol molecule make with the protein and adjacent substructures?
The cholesterol molecule makes significant interactions with the following residues; cholesterol (CLR412), ALA59, ILE55, THR73, CYS77, LEU80, VAL81, LEU84, ALA85, ILE112...
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