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Irritation of gut mucosa, excessive distention of the gut, or specific chemicals in the gut can stimulate these fibers to excite or inhibit. One of these has its cell bodies in the enteric nervous system and sends its axons through autonomic nerves to the prevertebral sympathetic ganglia.
Cholecystokinin (CCK) induces contraction of the gallbladder and inhibits stomach motility. CCK is secreted by the I cells of the duodenum and jejunum in response to breakdown products of fat, fatty acids, and monoglycerides. CCK is a competitive inhibitor of gastrin.
Gastrin increases HCl production and stomach motility...
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