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Although the actin isoforms exhibit minor sequence differences, they have different functions that can not be substituted by one another in vivo (3). In general, alpha-actin isoforms (?-skeletal, ?-aortic smooth, ?-cardiac, and ?2-enteric smooth) are found in muscle cells and they are associated with muscle contraction (3). Beta-actin and gamma-actin isoforms present in nonmusle cells (2). Beta-actin is at the front of a moving cell where actin filaments polymerize to drive the membrane forward (2). Gamma-actin is found in stress fibers, which are important for cell growth and cell movement (1)...
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