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Superficial cells elongate by cell division while flattening, which gives them greater surface area and thinner depth. The ectoderm eventually covers the entire embryo, internalizing the endoderm. This process sets up the correct position for the three germ layers, with the ectoderm on the outside, mesoderm in the middle and endoderm on the inside.
Keller (1980) found that superficial cells spread, divide, and undergo rearrangements and a temporary change in shape, which produces an increase in area. The deep cells become thinner and decrease in the number of layers. They do this by a process called radial interdigitation...
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