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Individuals with this form of DS are frequently a bit milder in their presentation, depending on the proportion of normal cells.
The third is a translocation DS, about 3-5% of the total, where part or all of chromosome 21 is translocated to another chromosome, usually 14. Translocation DS does not vary with age. Children with translocation DS are indistinguishable from individuals with the usual form of DS.
Trisomy 21
An extra whole chromosome 21 in all cells examined is found in about 92 per cent of all DS individuals. This is shown in Figure 1. DS is common enough that it may appear that there is an excess cluster or hot spot when several DS children are born in the same area, but this is just chance and statistical variation...
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