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Working with the fungi Neurospora and Penicillium, they found that "genes direct the formation of enzymes through the units of which they are composed." (Annas 1996) Each unit (a polypeptide) is produced by a specific gene. This work launched studies into the chemical nature of the gene and helped to establish the field of molecular genetics.
"The fact that chromosomes were almost entirely composed of two kinds of chemical substances, protein and nucleic acids, had long been known. Partly because of the close relationship established between genes and enzymes, which are proteins, protein at first seemed the fundamental substance that determined heredity...
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