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Essay text:
In principle, we can pick proteins with polymorphic amino acids and evaluate selective differences among them. In practice, however, the magnitudes of selective differences are generally so small that it is almost impossible to detect any significant differences in fitness1. Alternatively, adaptive evolution is strongly suggested by one type of protein having a strong association with a specific environment. Once a protein is suspected to be under positive darwinian selection, we can identify potentially important amino-acid replacements that may be responsible for adaptation. These hypotheses can then be tested experimentally (see figure)...
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Common topics in this essay:
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