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While stress does not cause the disease, it may precipitate a flare-up. Diagnosis is based on the patient. s symptoms, supported by x-rays and biopsies of the small and large intestine. Tumor necrosis factor alpha, TNFa, a protein released when the immune system is activated, is a major catalyst in the inflammatory process and is believed to play a major role in the pathogenesis of the disease.
Intestinal obstruction secondary to active inflammation is the most common complication. Patients with colonic involvement are at risk for developing colon cancer. Subsets of patients develop fistulas that are usually managed by medication or parental nutrition, but may require surgery...
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