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Although there are no uniform classifications on the degree of deterioration of the renal function attributed to the disease, The Kidney Disease Outcomes Quality Initiative (K/DOQI) of the National Kidney Foundation (NKF) provided the following classification:
Stage 1: Kidney damage with normal or increased GFR (>90 mL/min/1.73 m2)
Stage 2: Mild reduction in GFR (60-89 mL/min/1.73 m2)
Stage 3: Moderate reduction in GFR (30-59 mL/min/1.73 m2)
Stage 4: Severe reduction in GFR (15-29 mL/min/1.73 m2)
Stage 5: Kidney failure (GFR <15 mL/min/1.73 m2 or dialysis) (Verrelli, 2006)
Pathophysiology of the Disease
The Merck Manuals Online (2005) identified the general progression of the disease beginning at “diminished renal reserve, renal insufficiency, and renal failure (end-stage renal disease)...
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