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Essay text:
The NSCLC
Collaborative Group meta-analysis [3] showed that sequential
cisplatin-based chemotherapy given in addition to radical
radiotherapy prolonged survival in patients with locally
advanced NSCLC. However, the prognosis for these patients
remained poor with a 3-year survival rate of approximately
14%. Cytotoxic agents used as radiosensitisers given at the
same time as radiotherapy have been evaluated against
radiotherapy alone in several randomised trials [4–14].
A primary aim of this combined approach was to improve
survival by increasing loco-regional control, while the
sequential use of chemotherapy has been directed at reducing
the rate of distant metastasis...
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