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Plaque is composed of porridge like accumulation of cholesterol and their compounds within a fibrous coat. After it builds up, the injury to the arteries signal the immune system to release white blood cells to the site. This initiates a process called the inflammatory response. Macrophages literally "eat" the oxidized cholesterol leaving behind foamy cells that attach to the artery's smooth muscle cells. The foamy cells then buildup within the artery. After the immune system senses the foamy cells, it releases other factors called cytokines, which attract more white blood cells and perpetuate the whole cycle...
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