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The intrinsic pathway begins when platelets degranulate. They release factor XII. This leads to activated factors XI, IX, VIII, in that order. Each serving as the enzyme catalyzing the next step to factor X, which also require Ca2+ and Fe3+. Once factor X is activated steps are identical on the intrinsic and extrinsic pathways called the common pathway. Factor X combines with factors III and V in the presence of Ca2+ and PF3 to producw prothrombin activator. This enzyme acts on prothromboin (factor II) and converts it to the ezyme thrombin. Thrombin chops fibrinogen into strands of fibrin. Factor XIII cross links these shorter fibrin strands to create fibrin polymer, which forms the structural framework of the blood clot...
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