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Past influenza pandemics have led to high levels of illness, death, social disruption, and economic loss.
There are many different subtypes of Influenza or "flu" viruses. The subtypes differ based upon certain proteins on the surface of the virus (the hemagglutinin or "HA" protein and the neuraminidase or the "NA" protein).
Pandemic viruses appear (or "emerge") as a result of a process called "antigenic shift," which causes an abrupt or sudden, major change in influenza A viruses. These changes are caused by new combinations of the HA and/or NA proteins on the surface of the virus. This change results in a new influenza A virus subtype...
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