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It is possible that this sibling had abnormal chromosomes also, which could be the reason the pregnancy did not reach full term.
II. a. Jane should be advised that her children have a 50% chance of inheriting the gene. Due to the fact that the disease is a x-linked recessive trait, if Jane has a son and he inherits the affected chromosome he will have the disease and will most likely be a more severe case then in previous generations. If she has daughter she will have 50% chance of being a carrier and if so will then likely pass the gene onto future generations. Carol should receive the same counseling given to Jane and should also be advised to have her daughter, who is already showing signs of a mental handicap, tested for fragile x-syndrome...
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